Computational Modelling of Glucose Uptake in the Enterocyte
journal contributionposted on 13.01.2022, 03:31 authored by Nima Afshar, Soroush SafaeiSoroush Safaei, David NickersonDavid Nickerson, Peter J. Hunter, Vinod Suresh
We describe an implemented model of glucose absorption in the enterocyte, as previously published by Afshar et al. (2019), The model used mechanistic descriptions of all the responsible transporters and was built in the CellML framework. It was validated against published experimental data and implemented in a modular structure which allows each individual transporter to be edited independently from the other transport protein models. The composite model was then used to study the role of the sodium-glucose cotransporter (SGLT1) and the glucose transporter type 2 (GLUT2), along with the requirement for the existence of the apical Glut2 transporter, especially in the presence of high luminal glucose loads, in order to enhance the absorption. Here we demonstrate the reproduction of the figures in the original paper by using the associated model. EDITOR'S NOTE (v3): Instructions within the manuscript changed, in order to properly execute the model files. Spelling of author's name corrected in filenames. (v4): Abstract fixes.